Not to say there is not a whole sh!tton of great food in Manhattan, but I have found the best restaurants overall to be in Queens. Queens is where all of those cool "ethnic" groups actually live. Manhattan is just where we work and play.

Mythos, in my home village of Flushing, is one of my favorite Greek restaurants in Queens and all of New York City

(Disclosure: Mythos is a client of mine -- doesn't change the fact that they are amazing, though.)